Cross-presentation of adeno-associated virus serotype 2 capsids activates cytotoxic T cells but does not render hepatocytes effective cytolytic targets.

Wang, Lili; Figueredo, Joanita; Calcedo, Roberto; Lin, Jianping; Wilson, James M

Wang, Lili; Figueredo, Joanita; Calcedo, Roberto; Lin, Jianping; Wilson, James M.

Affiliation

Wang L; Gene Therapy Program, Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Hum Gene Ther ; 18(3): 185-94, 2007 Mar.

Article in En | MEDLINE | ID: mdl-17324107

Subject(s)

Capsid/immunology; Dependovirus/immunology; Genetic Vectors/immunology; Hepatocytes/immunology; T-Lymphocytes, Cytotoxic/immunology; Amino Acid Sequence; Animals; Cell Movement; Cross-Priming; Cytotoxicity Tests, Immunologic; Dependovirus/genetics; Epitope Mapping; Epitopes, T-Lymphocyte/chemistry; Epitopes, T-Lymphocyte/immunology; Genetic Vectors/genetics; Liver/cytology; Liver/immunology; Lymphocyte Activation; Mice; Molecular Sequence Data; Transduction, Genetic

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Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes, Cytotoxic / Capsid / Dependovirus / Hepatocytes / Genetic Vectors Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Hum Gene Ther Journal subject: GENETICA MEDICA / TERAPEUTICA Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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