Modulation of signal transducers and activators of transcription 1 and 3 signaling in melanoma by high-dose IFNalpha2b.

Wang, Wenjun; Edington, Howard D; Rao, Uma N M; Jukic, Drazen M; Land, Stephanie R; Ferrone, Soldano; Kirkwood, John M

Wang, Wenjun; Edington, Howard D; Rao, Uma N M; Jukic, Drazen M; Land, Stephanie R; Ferrone, Soldano; Kirkwood, John M.

Affiliation

Wang W; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh, Melanoma and Skin Cancer Program, University of Pittsburgh Cancer Institute. Pittsburgh, PA, USA.

Clin Cancer Res ; 13(5): 1523-31, 2007 Mar 01.

Article in En | MEDLINE | ID: mdl-17332298

Subject(s)

Interferon-alpha/therapeutic use; Melanoma/drug therapy; STAT1 Transcription Factor/drug effects; STAT3 Transcription Factor/drug effects; Skin Neoplasms/drug therapy; ATP Binding Cassette Transporter, Subfamily B, Member 3; ATP-Binding Cassette Transporters/drug effects; Adult; Aged; Biomarkers, Tumor/analysis; Dose-Response Relationship, Drug; Female; Humans; Immunohistochemistry; Interferon alpha-2; Lymphatic Metastasis/pathology; Male; Melanoma/mortality; Melanoma/pathology; Middle Aged; Neoadjuvant Therapy; Recombinant Proteins; Skin Neoplasms/mortality; Skin Neoplasms/pathology; Survival Analysis

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Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Interferon-alpha / STAT1 Transcription Factor / STAT3 Transcription Factor / Melanoma Type of study: Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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