The blockade of AMPA-kainate and NMDA receptors in the dorsal periaqueductal gray reduces the effects of diazepam withdrawal in rats.

Souza-Pinto, Luiz F S; Castilho, Vanessa M; Brandão, Marcus Lira; Nobre, Manoel Jorge

Souza-Pinto, Luiz F S; Castilho, Vanessa M; Brandão, Marcus Lira; Nobre, Manoel Jorge.

Affiliation

Souza-Pinto LF; Instituto de Neurociências & Comportamento - INeC, Campus USP, Av. Bandeirantes 3900, Monte Alegre, Ribeirão Preto-SP, 14040-901, Brazil.

Pharmacol Biochem Behav ; 87(2): 250-7, 2007.

Article in En | MEDLINE | ID: mdl-17537493

Subject(s)

Diazepam/adverse effects; Excitatory Amino Acid Antagonists/pharmacology; Hypnotics and Sedatives/adverse effects; Periaqueductal Gray/drug effects; Receptors, AMPA/antagonists & inhibitors; Receptors, Kainic Acid/antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors; Substance Withdrawal Syndrome/prevention & control; Substance Withdrawal Syndrome/psychology; 2-Amino-5-phosphonovalerate/analogs & derivatives; 2-Amino-5-phosphonovalerate/pharmacology; Animals; Conditioning, Operant/drug effects; Electroshock; Rats; Rats, Wistar; Reinforcement, Psychology; Synaptic Transmission/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Substance Withdrawal Syndrome / Periaqueductal Gray / Receptors, N-Methyl-D-Aspartate / Receptors, Kainic Acid / Receptors, AMPA / Excitatory Amino Acid Antagonists / Diazepam / Hypnotics and Sedatives Limits: Animals Language: En Journal: Pharmacol Biochem Behav Year: 2007 Document type: Article Affiliation country: Brazil Country of publication: United States

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