Simultaneous inhibition of COX-2 and 5-LOX activities augments growth arrest and death of premalignant and malignant human lung cell lines.

Schroeder, Claudia P; Yang, Peiying; Newman, Robert A; Lotan, Reuben

Schroeder, Claudia P; Yang, Peiying; Newman, Robert A; Lotan, Reuben.

Affiliation

Schroeder CP; Department of Thoracic, Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center Houston, TX 77030, USA.

J Exp Ther Oncol ; 6(3): 183-92, 2007.

Article in En | MEDLINE | ID: mdl-17552358

Subject(s)

Cyclooxygenase 2 Inhibitors/pharmacology; Indoles/pharmacology; Lipoxygenase Inhibitors/pharmacology; Lung Neoplasms/drug therapy; Pyrazoles/pharmacology; Quinolines/pharmacology; Sulfonamides/pharmacology; 5-Lipoxygenase-Activating Proteins; Apoptosis/drug effects; Blotting, Western; Carrier Proteins/antagonists & inhibitors; Celecoxib; Cell Cycle/drug effects; Cell Death/drug effects; Cell Division/drug effects; Cell Line, Tumor; Dinoprostone/pharmacology; Humans; Hydroxyeicosatetraenoic Acids/pharmacology; Leukotriene B4/pharmacology; Lung Neoplasms/pathology; Membrane Proteins/antagonists & inhibitors; Spectrometry, Mass, Electrospray Ionization

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Quinolines / Sulfonamides / Lipoxygenase Inhibitors / Cyclooxygenase 2 Inhibitors / Indoles / Lung Neoplasms Limits: Humans Language: En Journal: J Exp Ther Oncol Journal subject: NEOPLASIAS / TERAPIA POR MEDICAMENTOS Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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