Renin-angiotensin inhibition reverses advanced cardiac remodeling in aging spontaneously hypertensive rats.

Ito, Norihisa; Ohishi, Mitsuru; Yamamoto, Koichi; Tatara, Yuji; Shiota, Atsushi; Hayashi, Norihiro; Komai, Norio; Yanagitani, Yoshihiro; Rakugi, Hiromi; Ogihara, Toshio

Ito, Norihisa; Ohishi, Mitsuru; Yamamoto, Koichi; Tatara, Yuji; Shiota, Atsushi; Hayashi, Norihiro; Komai, Norio; Yanagitani, Yoshihiro; Rakugi, Hiromi; Ogihara, Toshio.

Affiliation

Ito N; Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan.

Am J Hypertens ; 20(7): 792-9, 2007 Jul.

Article in En | MEDLINE | ID: mdl-17586415

Subject(s)

Angiotensin II Type 1 Receptor Blockers/therapeutic use; Angiotensin-Converting Enzyme Inhibitors/therapeutic use; Cardiomegaly/drug therapy; Hypertension/drug therapy; Renin-Angiotensin System/drug effects; Aging/drug effects; Angiotensin II Type 1 Receptor Blockers/pharmacology; Angiotensin-Converting Enzyme Inhibitors/pharmacology; Animals; Biomarkers/metabolism; Blood Pressure/drug effects; Fibroblast Growth Factor 2/metabolism; Fibrosis/drug therapy; Male; Myocardium/metabolism; NADPH Oxidases/metabolism; Oxidative Stress/drug effects; Rats; Rats, Inbred SHR; Transforming Growth Factor beta1/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Renin-Angiotensin System / Angiotensin-Converting Enzyme Inhibitors / Cardiomegaly / Angiotensin II Type 1 Receptor Blockers / Hypertension Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Hypertens Journal subject: ANGIOLOGIA Year: 2007 Document type: Article Affiliation country: Japan

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