Low dose combination of morphine and delta9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors.

Smith, Paul A; Selley, Dana E; Sim-Selley, Laura J; Welch, Sandra P

Smith, Paul A; Selley, Dana E; Sim-Selley, Laura J; Welch, Sandra P.

Affiliation

Smith PA; Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University Medical College of Virginia, Richmond, VA 23298, United States.

Eur J Pharmacol ; 571(2-3): 129-37, 2007 Oct 01.

Article in En | MEDLINE | ID: mdl-17603035

Subject(s)

Analgesics, Non-Narcotic/pharmacology; Analgesics, Opioid/pharmacology; Dronabinol/pharmacology; Drug Tolerance; Morphine/pharmacology; Pain/prevention & control; Periaqueductal Gray/drug effects; Spinal Cord/drug effects; Analgesics, Non-Narcotic/administration & dosage; Analgesics, Non-Narcotic/therapeutic use; Analgesics, Opioid/administration & dosage; Analgesics, Opioid/therapeutic use; Animals; Benzoxazines/pharmacology; Dose-Response Relationship, Drug; Dronabinol/administration & dosage; Dronabinol/therapeutic use; Drug Synergism; Drug Therapy, Combination; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/pharmacology; Guanosine 5'-O-(3-Thiotriphosphate)/metabolism; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine/administration & dosage; Morphine/therapeutic use; Morpholines/pharmacology; Naphthalenes/pharmacology; Pain/metabolism; Pain/physiopathology; Pain Measurement; Pain Threshold/drug effects; Periaqueductal Gray/metabolism; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1/agonists; Receptor, Cannabinoid, CB1/metabolism; Receptors, Opioid, mu/agonists; Receptors, Opioid, mu/metabolism; Spinal Cord/metabolism; Sulfur Radioisotopes; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Spinal Cord / Dronabinol / Periaqueductal Gray / Analgesics, Non-Narcotic / Drug Tolerance / Analgesics, Opioid / Morphine Language: En Journal: Eur J Pharmacol Year: 2007 Document type: Article Affiliation country: United States Country of publication: Netherlands

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