Helt determines GABAergic over glutamatergic neuronal fate by repressing Ngn genes in the developing mesencephalon.

Nakatani, Tomoya; Minaki, Yasuko; Kumai, Minoru; Ono, Yuichi

Nakatani, Tomoya; Minaki, Yasuko; Kumai, Minoru; Ono, Yuichi.

Affiliation

Nakatani T; KAN Research Institute Inc., KobeMI R&D Center, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.

Development ; 134(15): 2783-93, 2007 Aug.

Article in En | MEDLINE | ID: mdl-17611227

Subject(s)

Basic Helix-Loop-Helix Transcription Factors/genetics; Basic Helix-Loop-Helix Transcription Factors/physiology; Glutamic Acid/metabolism; Mesencephalon/embryology; Nerve Tissue Proteins/genetics; Neurons/cytology; Repressor Proteins/physiology; gamma-Aminobutyric Acid/metabolism; Animals; Cell Differentiation/genetics; Down-Regulation; Gene Expression Regulation, Developmental; Homeobox Protein Nkx-2.2; Mesencephalon/cytology; Mesencephalon/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Nerve Tissue Proteins/physiology; Neurons/metabolism; Organ Specificity/genetics; Repressor Proteins/genetics; Stem Cells/cytology

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Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Mesencephalon / Glutamic Acid / Basic Helix-Loop-Helix Transcription Factors / Gamma-Aminobutyric Acid / Nerve Tissue Proteins / Neurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: Development Journal subject: BIOLOGIA / EMBRIOLOGIA Year: 2007 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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