Disturbance of DNA methylation patterns in the early phase of hepatocarcinogenesis induced by a choline-deficient L-amino acid-defined diet in rats.

Shimizu, Kyoko; Onishi, Mariko; Sugata, Eriko; Sokuza, Yui; Mori, Chiharu; Nishikawa, Tomoki; Honoki, Kanya; Tsujiuchi, Toshifumi

Shimizu, Kyoko; Onishi, Mariko; Sugata, Eriko; Sokuza, Yui; Mori, Chiharu; Nishikawa, Tomoki; Honoki, Kanya; Tsujiuchi, Toshifumi.

Affiliation

Shimizu K; Laboratory of Cancer Biology and Bioinformatics, Department of Life Science, Faculty of Science and Engineering, Kinki University, 3-4-1 Kowakae, Higashiosaka, Osaka 577-8502, Japan.

Cancer Sci ; 98(9): 1318-22, 2007 Sep.

Article in En | MEDLINE | ID: mdl-17640295

Subject(s)

Amino Acids/metabolism; Carcinoma, Hepatocellular/genetics; Carcinoma, Hepatocellular/metabolism; Choline Deficiency/metabolism; DNA Methylation; Diet/adverse effects; Liver Neoplasms, Experimental/genetics; Liver Neoplasms, Experimental/metabolism; Amino Acids/administration & dosage; Animals; Cadherins/genetics; Cadherins/metabolism; Carcinoma, Hepatocellular/etiology; Choline Deficiency/complications; Choline Deficiency/genetics; Connexin 26; Connexins/genetics; Connexins/metabolism; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases/biosynthesis; DNA (Cytosine-5-)-Methyltransferases/genetics; Gene Expression Regulation, Neoplastic; Liver Neoplasms, Experimental/etiology; Male; Proto-Oncogene Proteins c-fos/genetics; Proto-Oncogene Proteins c-fos/metabolism; Rats; Rats, Inbred F344; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Choline Deficiency / Carcinoma, Hepatocellular / DNA Methylation / Diet / Amino Acids / Liver Neoplasms, Experimental Type of study: Etiology_studies Limits: Animals Language: En Journal: Cancer Sci Year: 2007 Document type: Article Affiliation country: Japan

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