Adaptation of a multi-drug resistant strain of Plasmodium falciparum from Peru to Aotus lemurinus griseimembra, A. nancymaae, and A. vociferans monkeys.
Am J Trop Med Hyg
; 77(2): 261-5, 2007 Aug.
Article
in En
| MEDLINE
| ID: mdl-17690397
A strain of Plasmodium falciparum from Peru was adapted to splenectomized Aotus nancymaae and Aotus vociferans monkeys. The Peru 134/CDC strain of P. falciparum was shown to be resistant to treatment with chloroquine in monkeys and partially resistant to mefloquine and malarone. Genetic mutations in crt, dhfr, dhps, and cytochrome b genes conferring drug resistance were also determined for this Peruvian strain of P. falciparum.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plasmodium falciparum
/
Malaria, Falciparum
/
Aotidae
/
Disease Models, Animal
/
Monkey Diseases
Limits:
Animals
/
Humans
Country/Region as subject:
America do sul
/
Peru
Language:
En
Journal:
Am J Trop Med Hyg
Year:
2007
Document type:
Article
Affiliation country:
United States
Country of publication:
United States