A lipid microsphere vehicle for vinorelbine: Stability, safety and pharmacokinetics.

Zhang, Hong Yao; Tang, Xing; Li, Hong Ying; Liu, Xiao Liang

Zhang, Hong Yao; Tang, Xing; Li, Hong Ying; Liu, Xiao Liang.

Affiliation

Zhang HY; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.

Int J Pharm ; 348(1-2): 70-9, 2008 Feb 04.

Article in En | MEDLINE | ID: mdl-17719191

Subject(s)

Lipids/chemistry; Microspheres; Vinblastine/analogs & derivatives; Animals; Antineoplastic Agents, Phytogenic/administration & dosage; Antineoplastic Agents, Phytogenic/adverse effects; Antineoplastic Agents, Phytogenic/pharmacokinetics; Area Under Curve; Drug Hypersensitivity/etiology; Drug Stability; Ear/blood supply; Emulsions; Guinea Pigs; Hydrogen-Ion Concentration; Injections, Intravenous; Lecithins/chemistry; Male; Particle Size; Pharmaceutical Vehicles; Poloxamer/chemistry; Polysorbates/chemistry; Pressure; Rabbits; Rats; Rats, Wistar; Triglycerides/chemistry; Veins/drug effects; Veins/pathology; Vinblastine/chemistry; Vinblastine/pharmacokinetics; Vinorelbine

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Collection: 01-internacional Database: MEDLINE Main subject: Vinblastine / Lipids / Microspheres Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Int J Pharm Year: 2008 Document type: Article Country of publication: Netherlands

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