A covalent inhibitor targeting an intermediate conformation of the fusogenic subunit of the HIV-1 envelope complex.

Jacobs, Amy; Quraishi, Omar; Huang, Xicai; Bousquet-Gagnon, Nathalie; Nault, Geneviève; Francella, Nicholas; Alvord, W Gregory; Pham, Nga; Soucy, Chantal; Robitaille, Martin; Bridon, Dominique; Blumenthal, Robert

Jacobs, Amy; Quraishi, Omar; Huang, Xicai; Bousquet-Gagnon, Nathalie; Nault, Geneviève; Francella, Nicholas; Alvord, W Gregory; Pham, Nga; Soucy, Chantal; Robitaille, Martin; Bridon, Dominique; Blumenthal, Robert.

Affiliation

Jacobs A; Center for Cancer Research Nanobiology Program, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702, USA.

J Biol Chem ; 282(44): 32406-13, 2007 Nov 02.

Article in En | MEDLINE | ID: mdl-17726011

Subject(s)

Anti-HIV Agents/metabolism; HIV Envelope Protein gp41/chemistry; HIV-1/drug effects; Peptides/metabolism; Anti-HIV Agents/pharmacology; Chromatography, High Pressure Liquid; HIV Envelope Protein gp41/metabolism; HIV-1/chemistry; HIV-1/metabolism; Inhibitory Concentration 50; Models, Biological; Peptides/pharmacology; Protein Conformation; Protein Folding; Virus Internalization/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Peptides / HIV Envelope Protein gp41 / HIV-1 / Anti-HIV Agents Language: En Journal: J Biol Chem Year: 2007 Document type: Article Affiliation country: United States

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