Direct cardiac actions of erythropoietin (EPO): effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury.

Piuhola, Jarkko; Kerkelä, Risto; Keenan, Jacqueline I; Hampton, Mark B; Richards, A Mark; Pemberton, Chris J

Piuhola, Jarkko; Kerkelä, Risto; Keenan, Jacqueline I; Hampton, Mark B; Richards, A Mark; Pemberton, Chris J.

Affiliation

Piuhola J; Christchurch CardioEndocrine Research Group, University of Otago, Christchurch, New Zealand.

Clin Sci (Lond) ; 114(4): 293-304, 2008 Feb.

Article in En | MEDLINE | ID: mdl-17919123

Subject(s)

Erythropoietin/therapeutic use; Heart/metabolism; Myocardial Reperfusion Injury/drug therapy; Natriuretic Peptide, Brain/metabolism; Animals; Apoptosis/drug effects; Bosentan; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1/metabolism; Humans; Janus Kinase 2/metabolism; Male; Myocardial Contraction/drug effects; Myocardial Ischemia/physiopathology; Myocardial Ischemia/prevention & control; Myocardial Reperfusion Injury/enzymology; Myocardial Reperfusion Injury/physiopathology; Perfusion; Phosphorylation; Rats; Rats, Sprague-Dawley; Recombinant Proteins; STAT3 Transcription Factor/metabolism; Stimulation, Chemical; Sulfonamides/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Myocardial Reperfusion Injury / Erythropoietin / Natriuretic Peptide, Brain / Heart Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Clin Sci (Lond) Year: 2008 Document type: Article Affiliation country: New Zealand Country of publication: United kingdom

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