A clinical pharmacokinetic analysis of tegafur-uracil (UFT) plus leucovorin given in a new twice-daily oral administration schedule.

Etienne-Grimaldi, Marie-Christine; François, Eric; Cardot, Jean-Michel; Renée, Nicole; Douillard, Jean-Yves; Gamelin, Erick; Bennouna, Jaafar; Château, Yann; Milano, Gérard

Etienne-Grimaldi, Marie-Christine; François, Eric; Cardot, Jean-Michel; Renée, Nicole; Douillard, Jean-Yves; Gamelin, Erick; Bennouna, Jaafar; Château, Yann; Milano, Gérard.

Affiliation

Etienne-Grimaldi MC; Oncopharmacology Unit, Centre Antoine Lacassagne, Nice, France.

Clin Pharmacokinet ; 46(11): 953-63, 2007.

Article in En | MEDLINE | ID: mdl-17922560

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Colorectal Neoplasms/drug therapy; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols/administration & dosage; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid/methods; Colorectal Neoplasms/metabolism; Colorectal Neoplasms/pathology; Cross-Over Studies; Diarrhea/chemically induced; Female; Fluorouracil/administration & dosage; Fluorouracil/pharmacokinetics; Humans; Leucovorin/administration & dosage; Leucovorin/pharmacokinetics; Male; Middle Aged; Neoplasm Metastasis; Prodrugs; Sex Factors; Tegafur/administration & dosage; Tegafur/pharmacokinetics; Therapeutic Equivalency; Uracil/administration & dosage; Uracil/pharmacokinetics

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Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Antineoplastic Combined Chemotherapy Protocols Type of study: Clinical_trials / Prognostic_studies Aspects: Patient_preference Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Clin Pharmacokinet Year: 2007 Document type: Article Affiliation country: France

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