FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A.

Berry, Fred B; Skarie, Jonathan M; Mirzayans, Farideh; Fortin, Yannick; Hudson, Thomas J; Raymond, Vincent; Link, Brian A; Walter, Michael A

Berry, Fred B; Skarie, Jonathan M; Mirzayans, Farideh; Fortin, Yannick; Hudson, Thomas J; Raymond, Vincent; Link, Brian A; Walter, Michael A.

Affiliation

Berry FB; Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada. fberry@ualberta.ca

Hum Mol Genet ; 17(4): 490-505, 2008 Feb 15.

Article in En | MEDLINE | ID: mdl-17993506

Subject(s)

Eye/metabolism; Forkhead Transcription Factors/metabolism; Animals; Anterior Chamber/abnormalities; Binding Sites/genetics; Cell Survival/genetics; Cell Survival/physiology; Cells, Cultured; Eye/embryology; Forkhead Box Protein O1; Forkhead Transcription Factors/genetics; Gene Dosage; Glaucoma/genetics; HeLa Cells; Humans; Mutation; Oxidative Stress; Promoter Regions, Genetic; RNA, Messenger/genetics; RNA, Messenger/metabolism; RNA, Small Interfering/genetics; Trabecular Meshwork/cytology; Trabecular Meshwork/metabolism; Transcription, Genetic; Zebrafish/embryology; Zebrafish/genetics; Zebrafish/metabolism; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Forkhead Transcription Factors / Eye Limits: Animals / Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2008 Document type: Article Affiliation country: Canada Country of publication: United kingdom

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