Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.

Willingham, Stephen B; Bergstralh, Daniel T; O'Connor, William; Morrison, Amy C; Taxman, Debra J; Duncan, Joseph A; Barnoy, Shoshana; Venkatesan, Malabi M; Flavell, Richard A; Deshmukh, Mohanish; Hoffman, Hal M; Ting, Jenny P-Y

Willingham, Stephen B; Bergstralh, Daniel T; O'Connor, William; Morrison, Amy C; Taxman, Debra J; Duncan, Joseph A; Barnoy, Shoshana; Venkatesan, Malabi M; Flavell, Richard A; Deshmukh, Mohanish; Hoffman, Hal M; Ting, Jenny P-Y.

Affiliation

Willingham SB; Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Cell Host Microbe ; 2(3): 147-59, 2007 Sep 13.

Article in En | MEDLINE | ID: mdl-18005730

Subject(s)

Carrier Proteins/immunology; Cell Death/immunology; Cytoskeletal Proteins/immunology; Macrophages/microbiology; Shigella flexneri/pathogenicity; Adult; Aged; Animals; CARD Signaling Adaptor Proteins; Carrier Proteins/genetics; Caspase 1/immunology; Cathepsins/physiology; Cell Line; Cells, Cultured; Female; HMGB1 Protein/metabolism; Humans; Interleukin-1beta/immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; NLR Family, Pyrin Domain-Containing 3 Protein; Shigella flexneri/genetics; Virulence Factors/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Shigella flexneri / Carrier Proteins / Cell Death / Cytoskeletal Proteins / Macrophages Type of study: Prognostic_studies Limits: Adult / Aged / Animals / Female / Humans / Middle aged Language: En Journal: Cell Host Microbe Journal subject: MICROBIOLOGIA Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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