DNA methyltransferase 1 knockdown induces silenced CDH1 gene reexpression by demethylation of methylated CpG in hepatocellular carcinoma cell line SMMC-7721.

Fan, Hong; Zhao, Zhujiang; Quan, Yanmei; Xu, Jun; Zhang, Jianqiong; Xie, Wei

Fan, Hong; Zhao, Zhujiang; Quan, Yanmei; Xu, Jun; Zhang, Jianqiong; Xie, Wei.

Affiliation

Fan H; Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, Jiangsu Province, China. fanh@seu.edu.cn

Eur J Gastroenterol Hepatol ; 19(11): 952-61, 2007 Nov.

Article in En | MEDLINE | ID: mdl-18049164

Subject(s)

Cadherins/genetics; Carcinoma, Hepatocellular/genetics; CpG Islands; DNA (Cytosine-5-)-Methyltransferases/genetics; Gene Expression Regulation, Neoplastic; Liver Neoplasms/genetics; Antigens, CD; Apoptosis Regulatory Proteins/genetics; Blotting, Western/methods; Carcinoma, Hepatocellular/metabolism; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; DNA, Complementary/analysis; Decorin; Extracellular Matrix Proteins/genetics; Gene Expression Profiling/methods; Genetic Engineering/methods; Humans; Intramolecular Oxidoreductases/genetics; Liver Neoplasms/metabolism; Oligonucleotide Array Sequence Analysis; Prostaglandin-E Synthases; Proteoglycans/genetics; RNA Interference; RNA, Messenger/analysis; RNA, Small Interfering/pharmacology; RNA-Binding Proteins/genetics; Reverse Transcriptase Polymerase Chain Reaction/methods; Transfection/methods

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Collection: 01-internacional Database: MEDLINE Main subject: Cadherins / Gene Expression Regulation, Neoplastic / Carcinoma, Hepatocellular / CpG Islands / DNA (Cytosine-5-)-Methyltransferases / Liver Neoplasms Limits: Humans Language: En Journal: Eur J Gastroenterol Hepatol Journal subject: GASTROENTEROLOGIA Year: 2007 Document type: Article Affiliation country: China Country of publication: United kingdom

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