Breast Neoplasms/enzymology; Cell Cycle Proteins/metabolism; Extracellular Matrix/enzymology; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/metabolism; Animals; Apoptosis/physiology; Blotting, Western; Breast Neoplasms/genetics; Breast Neoplasms/therapy; Carcinoma, Ductal, Breast/enzymology; Carcinoma, Ductal, Breast/pathology; Carcinoma, Intraductal, Noninfiltrating/enzymology; Carcinoma, Intraductal, Noninfiltrating/pathology; Cell Cycle Proteins/antagonists & inhibitors; Cell Cycle Proteins/genetics; Cell Movement; Collagen; Drug Combinations; Female; Humans; In Situ Nick-End Labeling; Integrin beta1/metabolism; Laminin/metabolism; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Protein Serine-Threonine Kinases/antagonists & inhibitors; Protein Serine-Threonine Kinases/genetics; Proteoglycans; Proto-Oncogene Proteins/antagonists & inhibitors; Proto-Oncogene Proteins/genetics; RNA, Small Interfering/pharmacology; Vimentin/metabolism; Polo-Like Kinase 1