Inhibition by acetaminophen of neoplastic initiation elicited in rat liver by the DNA-reactive hepatocarcinogen N-acetyl-2-aminofluorene.

Williams, Gary M; Iatropoulos, Michael J; Jeffrey, Alan M; Duan, Jian-Dong; Perrone, Carmen E

Williams, Gary M; Iatropoulos, Michael J; Jeffrey, Alan M; Duan, Jian-Dong; Perrone, Carmen E.

Affiliation

Williams GM; Department of Pathology, New York Medical College, Valhalla, New York, USA. Gary_Williams@NYMC.edu

Eur J Cancer Prev ; 16(6): 528-34, 2007 Dec.

Article in En | MEDLINE | ID: mdl-18090125

Subject(s)

2-Acetylaminofluorene/analogs & derivatives; Acetaminophen/pharmacology; Acetaminophen/therapeutic use; Carcinoma, Hepatocellular/prevention & control; DNA Adducts/drug effects; Liver Neoplasms/prevention & control; Animals; Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Body Weight/drug effects; Carcinoma, Hepatocellular/chemically induced; Carcinoma, Hepatocellular/pathology; Cell Transformation, Neoplastic/drug effects; DNA Adducts/metabolism; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Liver/drug effects; Liver/metabolism; Liver Neoplasms/chemically induced; Liver Neoplasms/pathology; Male; Precancerous Conditions/chemically induced; Precancerous Conditions/pathology; Rats; Rats, Inbred F344

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Collection: 01-internacional Database: MEDLINE Main subject: 2-Acetylaminofluorene / Carcinoma, Hepatocellular / DNA Adducts / Liver Neoplasms / Acetaminophen Limits: Animals Language: En Journal: Eur J Cancer Prev Journal subject: NEOPLASIAS / SAUDE PUBLICA Year: 2007 Document type: Article Affiliation country: United States Country of publication: United kingdom

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