Mammalian target of rapamycin is the key effector of phosphatidylinositol-3-OH-initiated proliferative signals in the thyroid follicular epithelium.

Yeager, Nicole; Brewer, Charlene; Cai, Kathy Qi; Xu, Xiang-Xi; Di Cristofano, Antonio

Yeager, Nicole; Brewer, Charlene; Cai, Kathy Qi; Xu, Xiang-Xi; Di Cristofano, Antonio.

Affiliation

Yeager N; Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

Cancer Res ; 68(2): 444-9, 2008 Jan 15.

Article in En | MEDLINE | ID: mdl-18199538

Subject(s)

Cell Proliferation; Epithelium/physiology; Phosphatidylinositol 3-Kinases/metabolism; Protein Kinases/physiology; Thyroid Gland/physiology; Adenocarcinoma, Follicular/pathology; Animals; Cell Proliferation/drug effects; Cells, Cultured; Epithelium/metabolism; Everolimus; Humans; Mice; Mice, Transgenic; PTEN Phosphohydrolase/genetics; Protein Kinase Inhibitors/pharmacology; Protein Kinases/metabolism; Signal Transduction/physiology; Sirolimus/analogs & derivatives; Sirolimus/pharmacology; TOR Serine-Threonine Kinases; Thyroid Gland/metabolism; Thyroid Neoplasms/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / Thyroid Gland / Phosphatidylinositol 3-Kinases / Cell Proliferation / Epithelium Limits: Animals / Humans Language: En Journal: Cancer Res Year: 2008 Document type: Article Affiliation country: United States Country of publication: United States

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