Ghrelin agonist (TZP-101): safety, pharmacokinetics and pharmacodynamic evaluation in healthy volunteers: a phase I, first-in-human study.

Lasseter, Kenneth C; Shaughnessy, Laura; Cummings, David; Pezzullo, John C; Wargin, William; Gagnon, Rene; Oliva, Jesus; Kosutic, Gordana

Lasseter, Kenneth C; Shaughnessy, Laura; Cummings, David; Pezzullo, John C; Wargin, William; Gagnon, Rene; Oliva, Jesus; Kosutic, Gordana.

Affiliation

Lasseter KC; Pharmanet Development Group, Inc., Miami, Florida, USA.

J Clin Pharmacol ; 48(2): 193-202, 2008 Feb.

Article in En | MEDLINE | ID: mdl-18199894

Subject(s)

Ghrelin/agonists; Macrocyclic Compounds/pharmacokinetics; Adolescent; Adult; Area Under Curve; Blood Glucose/analysis; Bradycardia/chemically induced; Diarrhea/chemically induced; Dizziness/chemically induced; Dose-Response Relationship, Drug; Double-Blind Method; Female; Growth Hormone/blood; Half-Life; Headache/chemically induced; Humans; Infusions, Intravenous; Insulin/blood; Insulin-Like Growth Factor I/analysis; Macrocyclic Compounds/administration & dosage; Macrocyclic Compounds/adverse effects; Male; Middle Aged; Prospective Studies

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Macrocyclic Compounds / Ghrelin Type of study: Clinical_trials / Observational_studies / Prognostic_studies Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: En Journal: J Clin Pharmacol Year: 2008 Document type: Article Affiliation country: United States Country of publication: United kingdom

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