Supplementation of ascorbic acid and alpha-tocopherol prevents arsenic-induced protein oxidation and DNA damage induced by arsenic in rats.

Kadirvel, R; Sundaram, K; Mani, S; Samuel, S; Elango, N; Panneerselvam, C

Kadirvel, R; Sundaram, K; Mani, S; Samuel, S; Elango, N; Panneerselvam, C.

Affiliation

Kadirvel R; Department of Medical Biochemistry, Dr. AL Mudhaliar PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600 113, India.

Hum Exp Toxicol ; 26(12): 939-46, 2007 Dec.

Article in En | MEDLINE | ID: mdl-18375637

Subject(s)

Antioxidants/pharmacology; Arsenic Poisoning/prevention & control; Ascorbic Acid/pharmacology; DNA Damage/drug effects; Protein Carbonylation/drug effects; alpha-Tocopherol/pharmacology; Administration, Oral; Animals; Arsenic Poisoning/metabolism; Arsenites/toxicity; Comet Assay; Cross-Linking Reagents; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors/toxicity; Kidney/chemistry; Kidney/drug effects; Kidney/metabolism; Liver/chemistry; Liver/drug effects; Liver/metabolism; Male; Oxidative Stress/drug effects; Protein Carbonylation/physiology; Rats; Rats, Wistar; Sodium Compounds/toxicity; Water Supply

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ascorbic Acid / DNA Damage / Arsenic Poisoning / Alpha-Tocopherol / Protein Carbonylation / Antioxidants Limits: Animals Language: En Journal: Hum Exp Toxicol Journal subject: TOXICOLOGIA Year: 2007 Document type: Article Affiliation country: India Country of publication: United kingdom

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