G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase.

Takashima, Shin-Ichiro; Sugimoto, Naotoshi; Takuwa, Noriko; Okamoto, Yasuo; Yoshioka, Kazuaki; Takamura, Masayuki; Takata, Shigeo; Kaneko, Shuichi; Takuwa, Yoh

Takashima, Shin-Ichiro; Sugimoto, Naotoshi; Takuwa, Noriko; Okamoto, Yasuo; Yoshioka, Kazuaki; Takamura, Masayuki; Takata, Shigeo; Kaneko, Shuichi; Takuwa, Yoh.

Affiliation

Takashima S; Department of Physiology, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, Japan.

Cardiovasc Res ; 79(4): 689-97, 2008 Sep 01.

Article in En | MEDLINE | ID: mdl-18480127

Subject(s)

Cell Movement; GTP-Binding Protein alpha Subunits, G12-G13/metabolism; GTP-Binding Protein alpha Subunits, Gq-G11/metabolism; Lysophospholipids/metabolism; Muscle, Smooth, Vascular/enzymology; Receptors, Lysosphingolipid/metabolism; Sphingosine/analogs & derivatives; rac GTP-Binding Proteins/metabolism; rho GTP-Binding Proteins/metabolism; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/analogs & derivatives; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology; ADP Ribose Transferases/pharmacology; Animals; Botulinum Toxins/pharmacology; Calcium/metabolism; Cell Movement/drug effects; Cells, Cultured; Dose-Response Relationship, Drug; GTP-Binding Protein alpha Subunits, G12-G13/genetics; GTP-Binding Protein alpha Subunits, Gq-G11/genetics; Male; Muscle, Smooth, Vascular/drug effects; Protein Kinase C/metabolism; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Proteins c-sis/metabolism; Pyrazoles/pharmacology; Pyridines/pharmacology; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1/genetics; Receptor, Angiotensin, Type 1/metabolism; Receptors, Lysosphingolipid/antagonists & inhibitors; Recombinant Fusion Proteins/metabolism; Signal Transduction; Sphingosine/metabolism; Transfection; rac GTP-Binding Proteins/antagonists & inhibitors; rho-Associated Kinases/antagonists & inhibitors; rho-Associated Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sphingosine / Lysophospholipids / Cell Movement / Rho GTP-Binding Proteins / Rac GTP-Binding Proteins / GTP-Binding Protein alpha Subunits, G12-G13 / GTP-Binding Protein alpha Subunits, Gq-G11 / Receptors, Lysosphingolipid / Muscle, Smooth, Vascular Limits: Animals Language: En Journal: Cardiovasc Res Year: 2008 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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