Signal transducer and activator of transcription 4 (STAT4), but not IL-12 contributes to Pseudomonas aeruginosa-induced lung inflammation in mice.

O'Sullivan, Rory; Carrigan, Svetlana O; Marshall, Jean S; Lin, Tong-Jun

O'Sullivan, Rory; Carrigan, Svetlana O; Marshall, Jean S; Lin, Tong-Jun.

Affiliation

O'Sullivan R; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada B3K 6R8.

Immunobiology ; 213(6): 469-79, 2008.

Article in En | MEDLINE | ID: mdl-18514749

Subject(s)

Interleukin-12/metabolism; Interleukin-1/metabolism; Pneumonia, Bacterial/immunology; Pseudomonas Infections/immunology; STAT4 Transcription Factor/metabolism; Tumor Necrosis Factor-alpha/metabolism; Animals; Chemokine CXCL2/immunology; Chemokine CXCL2/metabolism; Interleukin-1/immunology; Interleukin-12/deficiency; Interleukin-12/immunology; Lung/immunology; Lung/microbiology; Mice; Mice, Inbred BALB C; Mice, Knockout; Neutrophil Infiltration; Neutrophils/immunology; Neutrophils/metabolism; Pneumonia, Bacterial/microbiology; Pseudomonas Infections/microbiology; Pseudomonas aeruginosa/immunology; Pseudomonas aeruginosa/metabolism; STAT4 Transcription Factor/deficiency; STAT4 Transcription Factor/immunology; Signal Transduction; Tumor Necrosis Factor-alpha/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pseudomonas Infections / Interleukin-1 / Tumor Necrosis Factor-alpha / Pneumonia, Bacterial / Interleukin-12 / STAT4 Transcription Factor Limits: Animals Language: En Journal: Immunobiology Year: 2008 Document type: Article Country of publication: Netherlands

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