Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages.

Ha, Soon-Duck; Martins, Andrew; Khazaie, Khashayarsha; Han, Jiahuai; Chan, Bosco M C; Kim, Sung Ouk

Ha, Soon-Duck; Martins, Andrew; Khazaie, Khashayarsha; Han, Jiahuai; Chan, Bosco M C; Kim, Sung Ouk.

Affiliation

Ha SD; Department of Microbiology and Immunology, Siebens-Drake Research Institute, University of Western Ontario, London, Ontario, Canada.

J Immunol ; 181(1): 690-7, 2008 Jul 01.

Article in En | MEDLINE | ID: mdl-18566436

Subject(s)

Cathepsin B/metabolism; Cell Membrane/metabolism; Macrophages/metabolism; Tumor Necrosis Factor-alpha/metabolism; Animals; Base Sequence; Cathepsin B/antagonists & inhibitors; Cathepsin B/deficiency; Cathepsin B/genetics; Cells, Cultured; Dipeptides/pharmacology; Enzyme Activation; Enzyme Inhibitors/pharmacology; Humans; Macrophages/drug effects; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Protein Processing, Post-Translational; Protein Transport

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Collection: 01-internacional Database: MEDLINE Main subject: Cathepsin B / Cell Membrane / Tumor Necrosis Factor-alpha / Macrophages Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Immunol Year: 2008 Document type: Article Affiliation country: Canada Country of publication: United States

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