Toxicity and intraocular properties of a novel long-acting anti-proliferative and anti-angiogenic compound IMS2186.

Falkenstein, Iryna A; Cheng, Lingyun; Wong-Staal, Flossie; Tammewar, Ajay M; Barron, Erin C; Silva, Gabriel A; Li, Qi-Xiang; Yu, Dehua; Hysell, Michelle; Liu, Guohong; Ke, Ning; Macdonald, James E; Freeman, William R

Falkenstein, Iryna A; Cheng, Lingyun; Wong-Staal, Flossie; Tammewar, Ajay M; Barron, Erin C; Silva, Gabriel A; Li, Qi-Xiang; Yu, Dehua; Hysell, Michelle; Liu, Guohong; Ke, Ning; Macdonald, James E; Freeman, William R.

Affiliation

Falkenstein IA; Joan and Irwin Jacobs Retina Center, Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, California, USA.

Curr Eye Res ; 33(7): 599-609, 2008 Jul.

Article in En | MEDLINE | ID: mdl-18600493

Subject(s)

Angiogenesis Inhibitors/toxicity; Choroidal Neovascularization/drug therapy; Chromones/toxicity; Angiogenesis Inhibitors/pharmacology; Animals; Cell Line; Cell Movement/drug effects; Cell Proliferation/drug effects; Choroidal Neovascularization/metabolism; Choroidal Neovascularization/pathology; Chromones/pharmacology; Dinoprostone/metabolism; Disease Models, Animal; Electroretinography/drug effects; Endothelium, Vascular/drug effects; Fibroblasts/drug effects; Fluorescein Angiography; Humans; Mice; NIH 3T3 Cells/drug effects; Pigment Epithelium of Eye/drug effects; Rabbits; Rats; Rats, Inbred BN; Tumor Cells, Cultured/drug effects; Umbilical Veins/cytology; Wound Healing/drug effects

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromones / Choroidal Neovascularization / Angiogenesis Inhibitors Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Curr Eye Res Year: 2008 Document type: Article Affiliation country: United States Country of publication: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google