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Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha.
Puppo, Maura; Battaglia, Florinda; Ottaviano, Catherine; Delfino, Silvana; Ribatti, Domenico; Varesio, Luigi; Bosco, Maria Carla.
Affiliation
  • Puppo M; Laboratory of Molecular Biology, G. Gaslini Institute, L.go Gerolamo Gaslini 5, 16147 Genova Quarto, Italy.
Mol Cancer Ther ; 7(7): 1974-84, 2008 Jul.
Article in En | MEDLINE | ID: mdl-18645007
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Topotecan / Vascular Endothelial Growth Factor A / Basic Helix-Loop-Helix Transcription Factors / Hypoxia-Inducible Factor 1, alpha Subunit / Neovascularization, Pathologic / Neuroblastoma Limits: Animals / Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2008 Document type: Article Affiliation country: Italy Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Topotecan / Vascular Endothelial Growth Factor A / Basic Helix-Loop-Helix Transcription Factors / Hypoxia-Inducible Factor 1, alpha Subunit / Neovascularization, Pathologic / Neuroblastoma Limits: Animals / Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2008 Document type: Article Affiliation country: Italy Country of publication: United States