Characterization of eltenac and novel COX-2 selective thiopheneacetic acid analogues in vitro and in vivo.

Klein, Thomas; Dullweber, Frank; Brehm, Christoph; Prinz, Walter; Baudler, Monika; Figala, Volker; Herrmann, Michael

Klein, Thomas; Dullweber, Frank; Brehm, Christoph; Prinz, Walter; Baudler, Monika; Figala, Volker; Herrmann, Michael.

Affiliation

Klein T; Department of Biochemistry, Nycomed GmbH, Byk-Gulden-Strasse 2, 78467 Constance, Germany.

Biochem Pharmacol ; 76(6): 717-25, 2008 Sep 15.

Article in En | MEDLINE | ID: mdl-18674517

Subject(s)

Acetic Acid/pharmacology; Aniline Compounds/pharmacology; Cyclooxygenase 2 Inhibitors/pharmacology; Cyclooxygenase 2/metabolism; Thiophenes/pharmacology; Acetic Acid/chemistry; Acetic Acid/therapeutic use; Aniline Compounds/chemistry; Aniline Compounds/therapeutic use; Animals; Cells, Cultured; Cyclooxygenase 2 Inhibitors/chemistry; Cyclooxygenase 2 Inhibitors/therapeutic use; Edema/drug therapy; Edema/enzymology; Female; Humans; Male; Rats; Rats, Sprague-Dawley; Stomach Ulcer/drug therapy; Stomach Ulcer/enzymology; Thiophenes/chemistry; Thiophenes/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiophenes / Acetic Acid / Cyclooxygenase 2 / Cyclooxygenase 2 Inhibitors / Aniline Compounds Limits: Animals / Female / Humans / Male Language: En Journal: Biochem Pharmacol Year: 2008 Document type: Article Affiliation country: Germany

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