DNA topoisomerase I inhibitors ameliorate seizure-like behaviors and paralysis in a Drosophila model of epilepsy.

Song, J; Parker, L; Hormozi, L; Tanouye, M A

Song, J; Parker, L; Hormozi, L; Tanouye, M A.

Affiliation

Song J; Department of Environmental Sciences, Policy and Management, Division of Organisms and Environment, University of California, Berkeley, Berkeley, CA 94720, USA.

Neuroscience ; 156(3): 722-8, 2008 Oct 15.

Article in En | MEDLINE | ID: mdl-18703119

Subject(s)

Camptothecin/therapeutic use; Enzyme Inhibitors/therapeutic use; Paralysis/drug therapy; Seizures/drug therapy; Analysis of Variance; Animals; Animals, Genetically Modified; Bromates/pharmacology; Bromates/therapeutic use; DNA Topoisomerases, Type I/genetics; DNA Topoisomerases, Type I/metabolism; Disease Models, Animal; Drosophila; Drosophila Proteins/genetics; Drug Administration Schedule; Electric Stimulation/methods; Electroshock/adverse effects; Epilepsy/complications; Epilepsy/etiology; Epilepsy/genetics; Evoked Potentials/drug effects; Evoked Potentials/radiation effects; Motor Neurons/drug effects; Motor Neurons/physiology; Motor Neurons/radiation effects; Muscle, Skeletal/pathology; Muscle, Skeletal/radiation effects; Mutation/genetics; Paralysis/etiology; Seizures/etiology; Topoisomerase I Inhibitors; Valproic Acid/pharmacology; Valproic Acid/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Paralysis / Seizures / Camptothecin / Enzyme Inhibitors Type of study: Etiology_studies Limits: Animals Language: En Journal: Neuroscience Year: 2008 Document type: Article Affiliation country: United States Country of publication: United States

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