Palladium-catalyzed carbonylation reactions of aryl bromides at atmospheric pressure: a general system based on Xantphos.
J Org Chem
; 73(18): 7102-7, 2008 Sep 19.
Article
in En
| MEDLINE
| ID: mdl-18720970
A method for the Pd-catalyzed carbonylation of aryl bromides has been developed using Xantphos as the ligand. This method is effective for the direct synthesis of Weinreb amides, primary and secondary benzamides, and methyl esters from the corresponding aryl bromides at atmospheric pressure. In addition, a putative catalytic intermediate, (Xanphos)Pd(Br)benzoyl, was prepared and an X-ray crystal structure was obtained revealing an unusual cis-coordination mode of Xantphos in this palladium-acyl complex.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Palladium
/
Phosphines
/
Xanthenes
/
Carbon Monoxide
/
Esters
/
Amides
/
Hydrocarbons, Brominated
Language:
En
Journal:
J Org Chem
Year:
2008
Document type:
Article
Affiliation country:
United States
Country of publication:
United States