Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects.

Mecca, María Montalto de; Bartel, Laura C; Castro, Carmen Rodríguez de; Castro, José A

Mecca, María Montalto de; Bartel, Laura C; Castro, Carmen Rodríguez de; Castro, José A.

Affiliation

Mecca MM; Centro de Investigaciones Toxicológicas (CEITOX-CITEFA/CONICET), Villa Martelli, Buenos Aires, Argentina.

Mem Inst Oswaldo Cruz ; 103(6): 549-53, 2008 Sep.

Article in En | MEDLINE | ID: mdl-18949324

Subject(s)

Heart/drug effects; Myocardium/metabolism; Nifurtimox/pharmacokinetics; Nitroimidazoles/pharmacokinetics; Trypanocidal Agents/pharmacokinetics; Animals; Biotransformation; Drug Evaluation, Preclinical; Male; Microscopy, Electron, Transmission; Microsomes/enzymology; Nifurtimox/adverse effects; Nitroimidazoles/adverse effects; Nitroreductases/analysis; Rats; Rats, Sprague-Dawley; Time Factors; Trypanocidal Agents/adverse effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanocidal Agents / Heart / Myocardium / Nifurtimox / Nitroimidazoles Limits: Animals Language: En Journal: Mem Inst Oswaldo Cruz Year: 2008 Document type: Article Affiliation country: Argentina Country of publication: Brazil

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