Humanizing a mouse gene for human therapeutics: lessons from denosumab.

Little, David Graham

Little, David Graham.

Affiliation

Little DG; Orthopaedic Research and Biotechnology, The Children's Hospital at Westmead, Westmead, New South Wales, Australia. davidl3@chw.edu.au

J Bone Miner Res ; 24(2): 179-81, 2009 Feb.

Article in En | MEDLINE | ID: mdl-19072067

Subject(s)

Antibodies, Monoclonal/therapeutic use; Genetic Engineering; RANK Ligand/therapeutic use; Acid Phosphatase/blood; Animals; Antibodies, Monoclonal, Humanized; Clinical Trials as Topic; Denosumab; Fractures, Bone/drug therapy; Humans; Isoenzymes/blood; Mice; RANK Ligand/metabolism; Tartrate-Resistant Acid Phosphatase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Engineering / RANK Ligand / Antibodies, Monoclonal Limits: Animals / Humans Language: En Journal: J Bone Miner Res Journal subject: METABOLISMO / ORTOPEDIA Year: 2009 Document type: Article Affiliation country: Australia Country of publication: United States

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