Classical Lissencephalies and Subcortical Band Heterotopias/genetics; Disease Models, Animal; Microtubule-Associated Proteins/genetics; Neuropeptides/genetics; Seizures/genetics; Animals; Animals, Genetically Modified; Cell Movement/genetics; Classical Lissencephalies and Subcortical Band Heterotopias/pathology; Classical Lissencephalies and Subcortical Band Heterotopias/therapy; Classical Lissencephalies and Subcortical Band Heterotopias/veterinary; Doublecortin Domain Proteins; Doublecortin Protein; Female; Gene Knockdown Techniques; Genetic Predisposition to Disease; Genetic Therapy; Malformations of Cortical Development, Group II/embryology; Malformations of Cortical Development, Group II/genetics; Malformations of Cortical Development, Group II/pathology; Malformations of Cortical Development, Group II/veterinary; Microtubule-Associated Proteins/antagonists & inhibitors; Microtubule-Associated Proteins/physiology; Models, Biological; Neurons/pathology; Neurons/physiology; Neuropeptides/antagonists & inhibitors; Neuropeptides/physiology; Pregnancy; RNA Interference/physiology; Rats; Seizures/pathology; Seizures/therapy; Severity of Illness Index