The vitamin D receptor agonist elocalcitol inhibits IL-8-dependent benign prostatic hyperplasia stromal cell proliferation and inflammatory response by targeting the RhoA/Rho kinase and NF-kappaB pathways.

Penna, Giuseppe; Fibbi, Benedetta; Amuchastegui, Susana; Corsiero, Elisa; Laverny, Gilles; Silvestrini, Enrico; Chavalmane, Aravinda; Morelli, Annamaria; Sarchielli, Erica; Vannelli, Gabriella Barbara; Gacci, Mauro; Colli, Enrico; Maggi, Mario; Adorini, Luciano

Penna, Giuseppe; Fibbi, Benedetta; Amuchastegui, Susana; Corsiero, Elisa; Laverny, Gilles; Silvestrini, Enrico; Chavalmane, Aravinda; Morelli, Annamaria; Sarchielli, Erica; Vannelli, Gabriella Barbara; Gacci, Mauro; Colli, Enrico; Maggi, Mario; Adorini, Luciano.

Affiliation

Penna G; BioXell, Milan, Italy.

Prostate ; 69(5): 480-93, 2009 Apr 01.

Article in En | MEDLINE | ID: mdl-19107880

Subject(s)

Calcitriol/analogs & derivatives; Interleukin-8/metabolism; NF-kappa B/metabolism; Prostatic Hyperplasia/pathology; rho-Associated Kinases/metabolism; rhoA GTP-Binding Protein/metabolism; Calcitriol/pharmacology; Cell Proliferation/drug effects; Cells, Cultured; Cyclooxygenase 2/metabolism; Dinoprostone/metabolism; Humans; Inflammation/metabolism; Inflammation/pathology; Interferon-gamma/pharmacology; Interleukin-17/pharmacology; Male; Prostatic Hyperplasia/metabolism; Receptors, Calcitriol/agonists; Signal Transduction/drug effects; Stromal Cells/metabolism; Stromal Cells/pathology; Tumor Necrosis Factor-alpha/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Hyperplasia / Calcitriol / Interleukin-8 / NF-kappa B / RhoA GTP-Binding Protein / Rho-Associated Kinases Limits: Humans / Male Language: En Journal: Prostate Year: 2009 Document type: Article Affiliation country: Italy Country of publication: United States

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