Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and modulating JNK and p38 mitogen-activated protein kinase pathways.

Li, Xiao-Ling; Xu, Gang; Chen, Tianfeng; Wong, Yum-Shing; Zhao, Hai-Lu; Fan, Rong-Rong; Gu, Xue-Mei; Tong, Peter C Y; Chan, Juliana C N

Li, Xiao-Ling; Xu, Gang; Chen, Tianfeng; Wong, Yum-Shing; Zhao, Hai-Lu; Fan, Rong-Rong; Gu, Xue-Mei; Tong, Peter C Y; Chan, Juliana C N.

Affiliation

Li XL; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.

Int J Biochem Cell Biol ; 41(7): 1526-35, 2009 Jul.

Article in En | MEDLINE | ID: mdl-19166964

Subject(s)

Amyloid/pharmacology; Apoptosis/drug effects; Cytoprotection/drug effects; Insulin-Secreting Cells/enzymology; JNK Mitogen-Activated Protein Kinases/metabolism; Phycocyanin/pharmacology; p38 Mitogen-Activated Protein Kinases/metabolism; Animals; Antioxidants/metabolism; Caspase 3/metabolism; Enzyme Activation/drug effects; Free Radicals/metabolism; Humans; Insulin-Secreting Cells/cytology; Insulin-Secreting Cells/drug effects; Islet Amyloid Polypeptide; Malondialdehyde/metabolism; Oxidative Stress/drug effects; Poly(ADP-ribose) Polymerases/metabolism; Rats

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phycocyanin / Apoptosis / Cytoprotection / JNK Mitogen-Activated Protein Kinases / P38 Mitogen-Activated Protein Kinases / Insulin-Secreting Cells / Amyloid Limits: Animals / Humans Language: En Journal: Int J Biochem Cell Biol Journal subject: BIOQUIMICA Year: 2009 Document type: Article Affiliation country: China Country of publication: Netherlands

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