Dehydromonocrotaline induces cyclosporine A-insensitive mitochondrial permeability transition/cytochrome c release.

dos Santos, Aline Buda; Dorta, Daniel Junqueira; Pestana, Cezar Rangel; Maioli, Marcos Antonio; Curti, Carlos; Mingatto, Fábio Erminio

dos Santos, Aline Buda; Dorta, Daniel Junqueira; Pestana, Cezar Rangel; Maioli, Marcos Antonio; Curti, Carlos; Mingatto, Fábio Erminio.

Affiliation

dos Santos AB; Laboratório de Bioquímica, Faculdade de Zootecnia, Universidade Estadual Paulista Júlio de Mesquita Filho, Campus de Dracena, 17900-000 Dracena, SP, Brazil.

Toxicon ; 54(1): 16-22, 2009 Jul.

Article in En | MEDLINE | ID: mdl-19285518

Subject(s)

Alkylating Agents/pharmacology; Cyclosporine/pharmacology; Cytochromes c/metabolism; Immunosuppressive Agents/pharmacology; Mitochondria/drug effects; Mitochondria/enzymology; Monocrotaline/analogs & derivatives; Animals; Apoptosis/drug effects; Calcium/metabolism; Glutathione/metabolism; Hydrogen Peroxide/metabolism; In Vitro Techniques; Lipid Peroxidation/drug effects; Male; Mitochondrial Membrane Transport Proteins/genetics; Mitochondrial Membrane Transport Proteins/metabolism; Mitochondrial Swelling/drug effects; Monocrotaline/pharmacology; NADP/metabolism; Permeability/drug effects; Rats; Rats, Wistar; Sulfhydryl Compounds/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monocrotaline / Cyclosporine / Cytochromes c / Alkylating Agents / Immunosuppressive Agents / Mitochondria Type of study: Observational_studies / Prognostic_studies Limits: Animals Language: En Journal: Toxicon Year: 2009 Document type: Article Affiliation country: Brazil Country of publication: United kingdom

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