AP-1, activator protein-1; COX-2, cyclooxygenase-2; EC, (­)-epicatechin; ECG, epicatechin-3-gallate; EGC, (­)-epigallocatechin; EGCG; EGCG, (­)-epigallocatechin-3-gallate; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; ERK, extracellular signal-regulated kinase; FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; HNSCC, head and neck squamous cell carcinoma; IGF-1, insulin-like growth factor-1; IGF-1R, insulin-like growth factor-1 receptor; IGFBP, insulin-like growth factor-binding protein; IKKα, inhibitor of κB kinase-α; IκBα, inhibitor of κB-α; LR, laminin receptor; MAPK, mitogen-activated protein kinase; MEK, mitogen-activated protein kinase kinase; MMP, matrix metalloproteinase; PDGF, platelet-derived growth factor; PDGFR, platelet-derived growth factor receptor; PGE2prostaglandin E2; PI3K, phosphatidylinositol 3-kinase; Poly E, polyphenon E; ROS, reactive oxygen species; RTK; RTK, receptor tyrosine kinase; Stat, signal transducers and activator of transcription; TGFα, transforming growth factor-α; TRAMP, transgenic adenocarcinoma of mouse prostate; Tea catechins; UV, ultraviolet; VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor; cell signaling pathway