Intestinal flora induces the expression of Cyp3a in the mouse liver.

Toda, T; Saito, N; Ikarashi, N; Ito, K; Yamamoto, M; Ishige, A; Watanabe, K; Sugiyama, K

Toda, T; Saito, N; Ikarashi, N; Ito, K; Yamamoto, M; Ishige, A; Watanabe, K; Sugiyama, K.

Affiliation

Toda T; Department of Clinical Pharmacokinetics, Hoshi University, Ebara, Shinagawa-ku, Tokyo, Japan.

Xenobiotica ; 39(4): 323-34, 2009 Apr.

Article in En | MEDLINE | ID: mdl-19350455

Subject(s)

Cytochrome P-450 Enzyme System/metabolism; Gene Expression Regulation, Enzymologic/drug effects; Intestines/microbiology; Liver/metabolism; RNA, Messenger/metabolism; Animals; Bacteria/chemistry; Blotting, Western; Chromatography, High Pressure Liquid; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; DNA Primers/genetics; Germ-Free Life; Isoenzymes/metabolism; Kinetics; Lithocholic Acid/pharmacology; Male; Mice; Oligonucleotide Array Sequence Analysis; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear/metabolism; Receptors, Steroid/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Specific Pathogen-Free Organisms; Transcription Factors/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / Gene Expression Regulation, Enzymologic / Cytochrome P-450 Enzyme System / Intestines / Liver Limits: Animals Language: En Journal: Xenobiotica Year: 2009 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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