Ethyl methanesulfonate toxicity in Viracept--a comprehensive human risk assessment based on threshold data for genotoxicity.

Müller, Lutz; Gocke, Elmar; Lavé, Thierry; Pfister, Thomas

Müller, Lutz; Gocke, Elmar; Lavé, Thierry; Pfister, Thomas.

Affiliation

Müller L; F. Hoffmann-La Roche Ltd., Nonclinical Safety, Grenzacher Strasse, 4070 Basel, Switzerland. lutz.mueller@roche.com

Toxicol Lett ; 190(3): 317-29, 2009 Nov 12.

Article in En | MEDLINE | ID: mdl-19443141

Subject(s)

Alkylating Agents/toxicity; Drug Contamination; Ethyl Methanesulfonate/toxicity; HIV Protease Inhibitors/chemistry; Mutagens/toxicity; Nelfinavir/chemistry; Toxicity Tests; Alkylating Agents/analysis; Alkylating Agents/pharmacokinetics; Animals; Dose-Response Relationship, Drug; Environmental Exposure; Ethyl Methanesulfonate/analysis; Ethyl Methanesulfonate/pharmacokinetics; Humans; Mice; Mutagens/analysis; Mutagens/pharmacokinetics; Mutation/drug effects; Neoplasms/chemically induced; No-Observed-Adverse-Effect Level; Rats; Reproduction/drug effects; Risk Assessment

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Contamination / HIV Protease Inhibitors / Toxicity Tests / Nelfinavir / Alkylating Agents / Ethyl Methanesulfonate / Mutagens Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Toxicol Lett Year: 2009 Document type: Article Affiliation country: Switzerland Country of publication: Netherlands

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