Gene Expression/drug effects; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects; Muscular Diseases/chemically induced; Quadriceps Muscle/drug effects; RNA/genetics; Ryanodine Receptor Calcium Release Channel/genetics; Adult; Aged; Aged, 80 and over; Biopsy; Creatine Kinase/blood; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use; Hypercholesterolemia/blood; Hypercholesterolemia/drug therapy; Immunohistochemistry; Male; Microscopy, Electron; Microscopy, Fluorescence; Middle Aged; Muscular Diseases/genetics; Muscular Diseases/metabolism; Myofibrils/drug effects; Myofibrils/metabolism; Myofibrils/ultrastructure; Prognosis; Quadriceps Muscle/metabolism; Quadriceps Muscle/ultrastructure; RNA/biosynthesis; Reverse Transcriptase Polymerase Chain Reaction; Ryanodine Receptor Calcium Release Channel/biosynthesis; Young Adult