Crystallographic analysis of bacterial signal peptidase in ternary complex with arylomycin A2 and a beta-sultam inhibitor.

Luo, Chuanyun; Roussel, Patrick; Dreier, Jürg; Page, Malcolm G P; Paetzel, Mark

Luo, Chuanyun; Roussel, Patrick; Dreier, Jürg; Page, Malcolm G P; Paetzel, Mark.

Affiliation

Luo C; Department of Molecular Biology and Biochemistry, Simon Fraser University, South Science Building 8888 University Drive, Burnaby, British Columbia, V5A 1S6 Canada.

Biochemistry ; 48(38): 8976-84, 2009 Sep 29.

Article in En | MEDLINE | ID: mdl-19655811

Subject(s)

Escherichia coli Proteins/chemistry; Membrane Proteins/chemistry; Oligopeptides/chemistry; Serine Endopeptidases/chemistry; Serine Proteinase Inhibitors/chemistry; Catalytic Domain; Crystallography, X-Ray; Escherichia coli Proteins/antagonists & inhibitors; Kinetics; Macromolecular Substances; Membrane Proteins/antagonists & inhibitors; Models, Molecular; Molecular Structure; Oligopeptides/pharmacology; Peptide Fragments/antagonists & inhibitors; Peptide Fragments/chemistry; Serine Proteinase Inhibitors/pharmacology; Static Electricity; Sulfonamides/chemistry; Sulfonamides/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Serine Endopeptidases / Serine Proteinase Inhibitors / Escherichia coli Proteins / Membrane Proteins Language: En Journal: Biochemistry Year: 2009 Document type: Article Country of publication: United States

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