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Role of cooperative binding on noise expression.
Gutierrez, P S; Monteoliva, D; Diambra, L.
Affiliation
  • Gutierrez PS; Laboratorio de Biología de Sistemas, CREG-UNLP, Av. Calchaqui Km 23.5, CP 1888, Florencio Varela, Argentina.
Phys Rev E Stat Nonlin Soft Matter Phys ; 80(1 Pt 1): 011914, 2009 Jul.
Article in En | MEDLINE | ID: mdl-19658736
The origin of stochastic fluctuations in gene expression has received considerable attention recently. Fluctuations in gene expression are particularly pronounced in cellular systems because of the small copy number of species undergoing transitions between discrete chemical states and the small size of biological compartments. In this paper, we propose a stochastic model for gene expression regulation including several binding sites, considering elementary reactions only. The model is used to investigate the role of cooperativity on the intrinsic fluctuations of gene expression by means of master-equation formalism. We found that the Hill coefficient and the level of noise increase as the interaction energy between activators increases. Additionally, we show that the model allows one to distinguish between two cooperative binding mechanisms.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Models, Biological Language: En Journal: Phys Rev E Stat Nonlin Soft Matter Phys Journal subject: BIOFISICA / FISIOLOGIA Year: 2009 Document type: Article Affiliation country: Argentina Country of publication: United States
Search on Google
Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Models, Biological Language: En Journal: Phys Rev E Stat Nonlin Soft Matter Phys Journal subject: BIOFISICA / FISIOLOGIA Year: 2009 Document type: Article Affiliation country: Argentina Country of publication: United States