5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination.

Larsen, Mie; Holm, René; Jensen, Klaus Gjervig; Sveigaard, Christina; Brodin, Birger; Nielsen, Carsten Uhd

Larsen, Mie; Holm, René; Jensen, Klaus Gjervig; Sveigaard, Christina; Brodin, Birger; Nielsen, Carsten Uhd.

Affiliation

Larsen M; Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

Eur J Pharm Sci ; 39(1-3): 68-75, 2010 Jan 31.

Article in En | MEDLINE | ID: mdl-19900542

Subject(s)

5-Hydroxytryptophan/adverse effects; Amino Acid Transport Systems/metabolism; Isoxazoles/pharmacokinetics; Organic Anion Transport Protein 1/metabolism; Symporters/metabolism; Amino Acid Transport Systems/antagonists & inhibitors; Animals; Biological Transport/drug effects; Caco-2 Cells; Drug Interactions; Gastric Emptying/drug effects; Humans; Intestinal Absorption/drug effects; Kinetics; Male; Oocytes/metabolism; Organic Anion Transport Protein 1/antagonists & inhibitors; Rats; Rats, Sprague-Dawley; Symporters/antagonists & inhibitors; Xenopus laevis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: 5-Hydroxytryptophan / Amino Acid Transport Systems / Organic Anion Transport Protein 1 / Symporters / Isoxazoles Limits: Animals / Humans / Male Language: En Journal: Eur J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2010 Document type: Article Affiliation country: Denmark Country of publication: Netherlands

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