Overview of genotoxic impurities in pharmaceutical development.

Bercu, Joel P; Dobo, Krista L; Gocke, Elmar; McGovern, Timothy J

Bercu, Joel P; Dobo, Krista L; Gocke, Elmar; McGovern, Timothy J.

Affiliation

Bercu JP; Eli Lilly and Company, Lilly Research Laboratories, Health Safety and Environmental, Indianapolis, IN 46285, USA. jpbercu@lilly.com

Int J Toxicol ; 28(6): 468-78, 2009.

Article in En | MEDLINE | ID: mdl-19966139

Subject(s)

Drug Contamination; Drug Discovery; Mutagens/toxicity; Pharmaceutical Preparations/chemical synthesis; Animals; Carcinogens/toxicity; Chemistry, Pharmaceutical; DNA/drug effects; DNA/genetics; DNA Damage; Dose-Response Relationship, Drug; Ethyl Methanesulfonate/toxicity; European Union; Humans; Legislation, Drug; Pharmaceutical Preparations/analysis; Pharmaceutical Preparations/chemistry; Risk Assessment; United States

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmaceutical Preparations / Drug Contamination / Drug Discovery / Mutagens Type of study: Etiology_studies / Guideline Limits: Animals / Humans Country/Region as subject: America do norte Language: En Journal: Int J Toxicol Journal subject: TOXICOLOGIA Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

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