Insertion mutations in herpes simplex virus 1 glycoprotein H reduce cell surface expression, slow the rate of cell fusion, or abrogate functions in cell fusion and viral entry.

Jackson, Julia O; Lin, Erick; Spear, Patricia G; Longnecker, Richard

Jackson, Julia O; Lin, Erick; Spear, Patricia G; Longnecker, Richard.

Affiliation

Jackson JO; Department of Microbiology and Immunology, the Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Ward 6-231, Chicago, IL 60611, USA.

J Virol ; 84(4): 2038-46, 2010 Feb.

Article in En | MEDLINE | ID: mdl-20007280

Subject(s)

Herpesvirus 1, Human/genetics; Herpesvirus 1, Human/physiology; Viral Envelope Proteins/genetics; Viral Envelope Proteins/physiology; Virus Internalization; Amino Acid Sequence; Animals; COS Cells; Chlorocebus aethiops; Genetic Complementation Test; Herpesvirus 1, Human/pathogenicity; Humans; Kinetics; Mutagenesis, Insertional; Protein Structure, Tertiary; Receptors, Tumor Necrosis Factor, Member 14/genetics; Receptors, Tumor Necrosis Factor, Member 14/physiology; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Vero Cells; Viral Envelope Proteins/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Envelope Proteins / Herpesvirus 1, Human / Virus Internalization Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Humans Language: En Journal: J Virol Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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