A novel calmodulin antagonist O-(4-ethoxyl-butyl)-berbamine overcomes multidrug resistance in drug-resistant MCF-7/ADR breast carcinoma cells.

Liu, Rong; Zhang, Yanjun; Chen, Yanhong; Qi, Jing; Ren, Simei; Xushi, Ming Yang; Yang, Chunzheng; Zhu, Huifang; Xiong, Dongsheng

Liu, Rong; Zhang, Yanjun; Chen, Yanhong; Qi, Jing; Ren, Simei; Xushi, Ming Yang; Yang, Chunzheng; Zhu, Huifang; Xiong, Dongsheng.

Affiliation

Liu R; State Key Laboratory of Experimental Hematology, Institute of Hematology & Hospital of Blood Disease, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.

J Pharm Sci ; 99(7): 3266-75, 2010 Jul.

Article in En | MEDLINE | ID: mdl-20112430

Subject(s)

Antibiotics, Antineoplastic/pharmacology; Benzylisoquinolines/pharmacology; Breast Neoplasms/drug therapy; Calmodulin/antagonists & inhibitors; Carcinoma/drug therapy; Doxorubicin/pharmacology; Drug Resistance, Multiple/drug effects; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Apoptosis/drug effects; Benzylisoquinolines/chemistry; CDC2 Protein Kinase; Calcium/metabolism; Cell Line, Tumor; Cyclin B/metabolism; Cyclin B1/metabolism; Cyclin-Dependent Kinase 4/metabolism; Cyclin-Dependent Kinases; Female; Humans; Rhodamine 123/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Calmodulin / Carcinoma / Doxorubicin / Drug Resistance, Multiple / Benzylisoquinolines / Antibiotics, Antineoplastic Limits: Female / Humans Language: En Journal: J Pharm Sci Year: 2010 Document type: Article Affiliation country: China Country of publication: United States

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