Regional variation in brain lactate in Leigh syndrome by localized 1H magnetic resonance spectroscopy.
Ann Neurol
; 29(2): 218-21, 1991 Feb.
Article
in En
| MEDLINE
| ID: mdl-2012390
Localized water-suppressed 1H magnetic resonance spectroscopy was performed in an 11-month-old infant with Leigh syndrome. Spectra obtained from the basal ganglia, occipital cortex, and brainstem showed elevations in lactate, which were most pronounced in regions where abnormalities were seen with routine T2-weighted magnetic resonance imaging. This approach has allowed us to examine metabolism in brain tissue directly and noninvasively, and may provide a sensitive means for evaluating metabolic disease and the response to therapy in the brain.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Leigh Disease
/
Lactates
Type of study:
Diagnostic_studies
Limits:
Female
/
Humans
/
Infant
Language:
En
Journal:
Ann Neurol
Year:
1991
Document type:
Article
Country of publication:
United States