Aldose reductase inhibitor fidarestat attenuates leukocyte-endothelial interactions in experimental diabetic rat retina in vivo.

Hattori, Tomoaki; Matsubara, Akihisa; Taniguchi, Kaori; Ogura, Yuichiro

Hattori, Tomoaki; Matsubara, Akihisa; Taniguchi, Kaori; Ogura, Yuichiro.

Affiliation

Hattori T; Department of Ophthalmology and Visual Sciences, Nagoya City University Graduate School of Medicine, 1 Kawasumi, Nagoya, Japan.

Curr Eye Res ; 35(2): 146-54, 2010 Feb.

Article in En | MEDLINE | ID: mdl-20136425

Subject(s)

Aldehyde Reductase/antagonists & inhibitors; Diabetic Retinopathy/prevention & control; Endothelium, Vascular/metabolism; Imidazolidines/administration & dosage; Leukocytes/metabolism; Retinal Vessels/drug effects; Acridine Orange; Administration, Oral; Animals; Blood Glucose/analysis; Diabetes Mellitus, Experimental/metabolism; Diabetes Mellitus, Experimental/prevention & control; Diabetic Retinopathy/metabolism; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; Fluorophotometry; Fructose/metabolism; Intercellular Adhesion Molecule-1/genetics; Male; Microscopy, Fluorescence; RNA, Messenger/metabolism; Rats; Rats, Long-Evans; Retinal Vessels/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Sorbitol/metabolism; Vascular Endothelial Growth Factor A/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Vessels / Endothelium, Vascular / Aldehyde Reductase / Imidazolidines / Diabetic Retinopathy / Leukocytes Type of study: Prognostic_studies Limits: Animals Language: En Journal: Curr Eye Res Year: 2010 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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