(Arene)Ru(II) complexes of epidermal growth factor receptor inhibiting tyrphostins with enhanced selectivity and cytotoxicity in cancer cells.

Biersack, B; Zoldakova, M; Effenberger, K; Schobert, R

Biersack, B; Zoldakova, M; Effenberger, K; Schobert, R.

Affiliation

Biersack B; Organic Chemistry Laboratory, University of Bayreuth, Universitaetsstrasse 30, 95440 Bayreuth, Germany.

Eur J Med Chem ; 45(5): 1972-5, 2010 May.

Article in En | MEDLINE | ID: mdl-20149940

Subject(s)

ErbB Receptors/antagonists & inhibitors; Organometallic Compounds/pharmacology; Ruthenium/chemistry; Tyrphostins/chemistry; Tyrphostins/pharmacology; Animals; Cell Proliferation/drug effects; DNA/drug effects; DNA/metabolism; Drug Discovery; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Male; Organometallic Compounds/chemical synthesis; Organometallic Compounds/chemistry; Salmon; Spermatozoa/metabolism; Structure-Activity Relationship; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organometallic Compounds / Ruthenium / Tyrphostins / ErbB Receptors Limits: Animals / Humans / Male Language: En Journal: Eur J Med Chem Year: 2010 Document type: Article Affiliation country: Germany Country of publication: France

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