Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding.

Oh-I, Shinsuke; Thaler, Joshua P; Ogimoto, Kayoko; Wisse, Brent E; Morton, Gregory J; Schwartz, Michael W

Oh-I, Shinsuke; Thaler, Joshua P; Ogimoto, Kayoko; Wisse, Brent E; Morton, Gregory J; Schwartz, Michael W.

Affiliation

Oh-I S; UW Medicine at South Lake Union, Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, 815 Mercer St., Seattle, WA 98109, USA.

Am J Physiol Endocrinol Metab ; 299(1): E47-53, 2010 Jul.

Article in En | MEDLINE | ID: mdl-20371733

Subject(s)

Dietary Fats/administration & dosage; Energy Metabolism/physiology; Hypothalamus/physiopathology; Inflammation/physiopathology; Interleukin-4/pharmacology; Obesity/physiopathology; Animals; Blood Glucose/analysis; Body Weight/physiology; Dietary Fats/metabolism; Heterocyclic Compounds, 3-Ring/pharmacology; I-kappa B Kinase/antagonists & inhibitors; Insulin/blood; Leptin/blood; Macrophage Activation/physiology; Male; Pyridines/pharmacology; Rats; Rats, Wistar; Specific Pathogen-Free Organisms

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dietary Fats / Interleukin-4 / Energy Metabolism / Hypothalamus / Inflammation / Obesity Limits: Animals Language: En Journal: Am J Physiol Endocrinol Metab Journal subject: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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