Local delivery of angiotensin II receptor blockers into the kidney passively attenuates inflammatory reactions during the early phases of streptozotocin-induced diabetic nephropathy through inhibition of calpain activity.

Kamal, Fadia; Yanakieva-Georgieva, Nadezhda; Piao, Honglan; Morioka, Tetsuo; Oite, Takashi

Kamal, Fadia; Yanakieva-Georgieva, Nadezhda; Piao, Honglan; Morioka, Tetsuo; Oite, Takashi.

Affiliation

Kamal F; Department of Cellular Physiology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Nephron Exp Nephrol ; 115(3): e69-79, 2010.

Article in En | MEDLINE | ID: mdl-20424485

Subject(s)

Calpain/antagonists & inhibitors; Diabetic Nephropathies/drug therapy; Tetrazoles/therapeutic use; Valine/analogs & derivatives; Angiotensin II Type 1 Receptor Blockers/therapeutic use; Animals; Diabetes Mellitus, Experimental/drug therapy; Inflammation/drug therapy; Kidney Glomerulus/drug effects; Kidney Glomerulus/physiopathology; Male; NF-kappa B/metabolism; Nitric Oxide Synthase Type III/metabolism; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System/drug effects; Streptozocin; Transcription Factor RelA/metabolism; Valine/therapeutic use; Valsartan

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tetrazoles / Valine / Calpain / Diabetic Nephropathies Limits: Animals Language: En Journal: Nephron Exp Nephrol Journal subject: NEFROLOGIA Year: 2010 Document type: Article Affiliation country: Japan Country of publication: Switzerland

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